Roads to the development of improved pertussis vaccines paved by immunology
نویسندگان
چکیده
منابع مشابه
Roads to the development of improved pertussis vaccines paved by immunology
Current acellular pertussis vaccines have various shortcomings, which may contribute to their suboptimal efficacy and waning immunity in vaccinated populations. This calls for the development of new pertussis vaccines capable of inducing long-lived protective immunity. Immunization with whole cell pertussis vaccines and natural infection with Bordetella pertussis induce distinct and more protec...
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متن کاملPertussis Vaccines
s of references provided in the position paper and GRADE tables Amirthalingam G, Andrews N, Campbell H, Ribeiro S, Kara E, Donegan K, et al. Effectiveness of maternal pertussis vaccination in England: an observational study. Lancet 2014 Oct 25; 384(9953):1521-1528. BACKGROUND: In October, 2012, a pertussis vaccination programme for pregnant women was introduced in response to an outbreak acro...
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Bordetella pertussis is a human-specific pathogen that causes whooping cough. The use of pertussis whole-cell vaccines in infants and toddlers led to decreased circulation of the bacterium in the child population and a marked decrease in the incidence of the disease. However, vaccine does not result in life-long immunity; indeed, the circulation of the bacterium has not been controlled in the a...
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ژورنال
عنوان ژورنال: Pathogens and Disease
سال: 2015
ISSN: 2049-632X,2049-632X
DOI: 10.1093/femspd/ftv067